Of course, some adjustments would have to be made to maps, including orientation and scale.
In the beginning hex is the Keep, the Caves of Chaos and I would use Prey of Darkness for the Cave of the Unknown.
"Prey of Darkness is a Universal Playing aid which details a force of brigands and their advisors, followers, and slaves. Each of the brigands has a price on his or her head. You have been charged with their capture! Can you bring them back to face trial alive, or must you kill them in order to collect the reward? Can you even survive the attempt? Send your heroes and heroines in search of Red Honohon and Black M'Dabb. This scenario can also be used for evil characters that need manpower to accomplish their goals. Join Red and Black in their endeavors to become rich and powerful. Become a brigand and terrorize the countryside! Challenge Red and Black for the leadership of the brigand force! All this and more await you!"
The river that flows out of the SE corner of the B2 Wilderness Map would turn south and be the river that goes north to south on the Wilderness Map from the Illhiedrin Book.
"A search by a beautiful Wizardress involves the recovery of the fabulous Illhiedrin Book, lost during a raging storm amid bolts of lightning in a titanic battle between an inhuman creature and a now-dead Wizard who was the former possessor of the Book. They party must recover the Book, defeat the Creature, and stay alive in the process. This Scenario is designed for use with low-level characters and includes wilderness maps, dungeon maps and inhabitants, plus the dangers of a lost city."
The road that exits at the NE corner of the B2 Wilderness Map would lead to Fortress Badabaskor.
"An adventure in the wilderness stronghold of a band of brigands that includes the background and statistics of an evil local deity, plus history, maps, and keyed room descriptions of a five-level dungeon carved out of the side of a mountain. The first three levels are fairly easy and suitable for breaking in new and inexperienced players; but the lower two are far tougher, and include a cavern that has a series of four dragon dens, indicative of the difficulty of the lower levels."
Beyond the Valley of Fixation would be the Citadel of Fire.
"This is the ancient stronghold of Yrammag with six tower levels and five dungeon levels. It is designed for very advanced characters, and includes encounters with everything from giant rats to a minotaur and a demon. Tables have been provided for the random location and activity of the great Trammag, so that it will be a surprise each time the dungeon is entered by the adventurers. The surrounding wilderness is mapped out according to our Campaign Hexagon System, and Yrammag's spells are listed to provide a complete and detailed dungeon adventure, created and officially approved for use with D&D."
I could then round it out using the Book of Treasure Maps.
The next question would be, "What ruleset?"
OD&D (or S&W)?
Maybe Holmes? I kinda like this idea...